One in eight couples has trouble conceiving. Do you know how many of the cases are caused by unexplained male infertility? Nearly a quarter. For years, scientists have known that infertility can be linked to sperm that fail to throw out histones from DNA during development, but the reasons for this failure and how it happens is unclear. Now, however, that lack of clarity may be changing.
Promising new research out of Penn Medicine is showing the precise location of the retained histones and the key gene that regulates them. Researchers have also created a mouse model with a mutated version of the gene. This allows investigators to track the defects in sperm, starting with the early stages of sperm development and going through fertilization. This research could lead us to a better understanding of infertility in men, and how epigenetic mutations are passed to future generations.
What does it mean, when sperm fail to evict histones? Histones are the main proteins in chromatin. Their function is to package DNA and turn genes on and off. Healthy sperm lose about 90-95 percent of these proteins, replacing them with protamines, smaller proteins able to pack DNA into tiny sperm. When a man has unexplained infertility, the problem is often with retained histones. The sperm count can be normal, the sperm have normal motility, and yet because the histones are in the wrong location, the couple has trouble conceiving.
Until now, research has produced conflicting results about where these histones are located. Because of the confusion of discrepant data, the burden of assisted-reproductive technologies has continued to fall on women. Even if the male has the issue, the female partner goes through hormone injections and procedures to promote a higher fertility rate.
Imagine, then, if scientists were able to use epigenetic therapies to change the levels of histones and protamines in men. With this new research, scientists are better able to closely study the mechanisms behind a mutated sperm’s trajectory, which opens the door to potential therapeutic treatments. Epigenetic drugs are already being used to treat cancer and other diseases. With a clearer understanding of how a man’s epigenome affects conception and embryonic development, we have the potential to alter sperm, so these new studies may lead to a breakthrough infertility treatment.
If you’re struggling with infertility or considering a vasectomy reversal, the Center for Vasectomy Reversal is here to help. Under the direction of Dr. Joshua Green, our team provides state-of-the-art treatment for men who need a reversal of their vasectomy or have other concerns about their fertility. We accept major credit cards as well as cash and checks, and offer a payment plan for those who are unable to pay the entire fee at the time of surgery. Whether you’re ready to schedule a procedure or just want to learn more, you can contact us through our website, or call 941-894-6428 to arrange a free consultation.
Vasectomy reversals have a high success rate, and many men and their partners are able to conceive naturally after having a vasectomy reversed. However, reaching optimal sperm production after having the surgery can take as long as six to twelve months. Why so long? More importantly, is there anything that can be done to optimize your sperm count after a vasectomy reversal?
To understand sperm count, it’s helpful to know a little bit about sperm production. A sperm cycle is usually about 90 days. That’s the amount of time it takes for your body to produce new sperm and get rid of the old sperm through ejaculation. After a vasectomy reversal, when a man goes in for his six–week postoperative semen analysis, the sperm motility is typically still low, because the man is still working on getting rid of old, dead, sperm found in the ejaculate. For most men, it takes about two sperm cycles, or six months, to achieve good sperm quality.
If your vasectomy reversal was done by an experienced, well-qualified, specially trained microsurgeon, you can rest assured that your sperm counts will eventually rise as your body returns to optimal sperm production. It’s important to be patient, though, and understand that this process will take some time. While you wait, there are some things you can do to help boost your sperm count.
- Take your recovery seriously. For a couple of weeks after your surgery, it’s important to take it easy, minimizing straining, pulling, lifting, and stretching. Even everyday actions like getting in and out of a car can cause strain, so be sure to follow your doctor’s instructions to the letter.
- Don’t rush back into sex. After a vasectomy reversal, wait three to four weeks before resuming sexual activity. Once the waiting period is over, though, frequent ejaculation is a great way to keep the sperm flowing through your tubes, which helps keep them open.
- Eat a nutrient-dense diet. While vitamin and antioxidants in supplement form may help, there’s really no substitute for a well-balanced diet that’s packed with vegetables and fruits.
- Take anti-inflammatories if your doctor recommends them. At the post-operative check, your doctor can tell you whether there is scarring at the surgical site, which can be improved with anti-inflammatory medications.
- Stay out of the hot tub. High water temperatures can kill healthy sperm, so avoid excessive heat.
- Watch your alcohol consumption, and don’t smoke. Alcohol can impair sperm production, and smoking slows wound healing.
- Follow up with your doctor. It’s important to keep all the recommended follow-up appointments so that your doctor can monitor your progress and make sure you’re healing correctly.
If you’re considering a vasectomy reversal, the Center for Vasectomy Reversal is here to help. Under the direction of Dr. Joshua Green, our caring and skilled team provides state-of-the-art treatment for men who need a reversal of their vasectomy or have other concerns about their fertility. We accept major credit cards as well as cash and checks, and we also offer a payment plan option for those who are unable to pay the entire fee at the time of surgery. Whether you’re ready to schedule a procedure or just have questions and want to learn more, you can contact us through our website, or call 941-894-6428 to arrange a free consultation.
Couples who are experiencing male infertility may have sperm function testing done, particularly if the male partner had a vasectomy reversal surgery. Sperm function testing is similar to semen analysis, but they aren’t quite the same test. A sperm function test will help the male infertility specialist develop a customized treatment plan that can help the couple achieve pregnancy.
First, the man must provide a sample of semen, which is examined in a laboratory. The lab technician will examine many aspects of the medical sample, including the total semen volume and the sperm density. The sperm density refers to the number of sperm present in the semen. A typical density is greater than 20 million sperm for each milliliter of semen. The lab technician will also examine the sperm motility (how well it moves), sperm morphology (shape of the sperm), and the presence of white blood cells. High amounts of white blood cells may indicate that an infection or inflammation could be affecting the sperm.
Dr. Joshua Green has helped countless couples overcome male infertility caused by vasectomies. Call the Center for Vasectomy Reversal in Sarasota at (941) 894-6428 to discuss your options, which may include sperm aspiration.
When you decide to undergo a vasectomy reversal, you don’t want a low sperm count to interfere with your fertility. Unfortunately, there are a number of things that can affect your sperm count and compound male infertility issues.
Watch this video for insight into some surprising things that could be interfering with your ability to start a family. For instance, keeping your cellphone in your pocket could negatively affect your sperm count.
At the Center for Vasectomy Reversal in Sarasota , Dr. Green is dedicated to helping couples overcome the problem of male infertility and create the families they want. For more information about vasectomy reversal and to find out how to book an appointment with Dr. Green, please call us today at (941) 894-6428.
After having a vasectomy reversal, you may have several semen analysis tests to determine whether sperm is once again present in your semen, and, if so, what your sperm count is. When you watch this featured video, you’ll learn the basics of semen analysis results. For example, a normal sperm count is anywhere from 40 to 300 million. A count below 10 million is considered quite low.
It’s considered alright for a sperm count to be no lower than 20 million, as long as the motility and morphology of the sperm are normal. This video also discusses the factors that might affect the results of the semen analysis and how normal sperm motility is defined.
If you’re looking for a vasectomy reversal surgeon in Sarasota, look no further than Dr. Joshua Green at the Center for Vasectomy Reversal. Call us today at (941) 894-6428 to discuss your male infertility concerns.
When you’re dealing with male infertility, seeking the counsel of a doctor is the most effective choice to overcome the problem. Men who have had a vasectomy must also undergo vasectomy reversals. However, it can be helpful to make lifestyle changes to complement medical intervention. When you watch this video, you’ll hear about some foods you can include in your diet to support your sperm count.
For instance, the high levels of amino acids in oysters can boost testosterone production in men. The amino acids in dark chocolate can double your sperm count and semen volume. This video also covers the benefits of asparagus, bananas, walnuts, pumpkin seeds, and other foods for overcoming male infertility.
If you’ve changed your mind about your family planning decisions , you can turn to Dr. Joshua Green of the Center for Vasectomy Reversal and Male Infertility. Call (941) 961-4581 to schedule a consultation to discuss our infertility procedures in Sarasota.
- Sperm Retrieval
- vasectomy reversal
- Dr. Green
- sperm count
- male infertility
- medical care
- low sperm count
- male fertility testing
- sperm aspiration
- semen analysis
- post-vasectomy pain syndrome
- anti-sperm antibodies
- older dad
- general anesthesia
- gender reveal party
- post-operative infections
- baby name
- baby's first year
- fertilization process
- spinal anesthesia
- ACS Fellow
- nutrition tips
- concierge-level care
- fertility planning app
- out-of-town patients
- post-vasectomy reversal
- sperm quality
- baby registry
- surgical care
- surgical consultation process
- prostate cancer